|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In humans, the short allele of a common polymorphism in the serotonin transporter (5-HTT) gene is associated with a higher risk to develop depression and anxiety disorders.
|
31849623 |
2019 |
|
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
5-HTT knockout mice, lacking the 5-HTT gene either homo- or heterozygously, provide a widely used model organism for the study of symptoms related to human anxiety disorders.
|
31849623 |
2019 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In humans, the short allele of a common polymorphism in the serotonin transporter (5-HTT) gene is associated with a higher risk to develop depression and anxiety disorders.
|
31849623 |
2019 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
In humans, the short allele of a common polymorphism in the serotonin transporter (5-HTT) gene is associated with a higher risk to develop depression and anxiety disorders.
|
31849623 |
2019 |
|
Recurrent aphthous ulcer
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.
|
31846848 |
2020 |
|
Anorexia Nervosa
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Increased rsFC in the salience network mediated the link between SLC6A4 methylation and eating disorder symptoms in patients with anorexia nervosa.
|
31823595 |
2019 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Epigenetic variation in the serotonin transporter gene (SLC6A4) has been shown to modulate the functioning of brain circuitry associated with the salience network and may heighten the risk for mental illness.
|
31823595 |
2019 |
|
Eating Disorders
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Increased rsFC in the salience network mediated the link between SLC6A4 methylation and eating disorder symptoms in patients with anorexia nervosa.
|
31823595 |
2019 |
|
Substance abuse problem
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
While, there was no genetic association between the 5-HTTLPR (LL, LS, SS), rs25331 (AA, AG, GG) and tri-allelic (SASA, LASG, LASA, LALG, LALA) genotypes (P = 0.26, 0.71 and 0.52, respectively) and SUD.
|
31809838 |
2020 |
|
Anorexia Nervosa
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Increased rsFC in the salience network mediated the link between SLC6A4 methylation and eating disorder symptoms in patients with anorexia nervosa.
|
31804778 |
2019 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Epigenetic variation in the serotonin transporter gene (SLC6A4) has been shown to modulate the functioning of brain circuitry associated with the salience network and may heighten the risk for mental illness.
|
31804778 |
2019 |
|
Eating Disorders
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Increased rsFC in the salience network mediated the link between SLC6A4 methylation and eating disorder symptoms in patients with anorexia nervosa.
|
31804778 |
2019 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients.
|
31792367 |
2019 |
|
Sexual Dysfunction
|
0.030 |
GeneticVariation
|
group |
BEFREE |
It was also demonstrated that patients receiving SERT, carrying T allele of HTR2A or L allele of 5-HTTLPR more likely to experience SD.
|
31792367 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1.
|
31784962 |
2019 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1.
|
31784962 |
2019 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1.
|
31784962 |
2019 |
|
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Compound S6, characterized by partial D<sub>2</sub> R agonism, 5-HT<sub>1A</sub> R agonism, 5-HT<sub>2A</sub> R antagonism, and blockade of SERT activities, was found to decrease psychosis- and depressive-like symptoms in rodents.
|
31746558 |
2019 |
|
Nonorganic psychosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compound S6, characterized by partial D<sub>2</sub> R agonism, 5-HT<sub>1A</sub> R agonism, 5-HT<sub>2A</sub> R antagonism, and blockade of SERT activities, was found to decrease psychosis- and depressive-like symptoms in rodents.
|
31746558 |
2019 |
|
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
However, G x E interactions of 5-HTTLPR with high emotional impact and prior lifetime anxiety disorders were statistically significant.
|
31727442 |
2019 |
|
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results provide new evidence of the modulation effect of the 5-HTTLPR polymorphisms on PTSD risk.
|
31727442 |
2019 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Suicidal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that, consistent with the gene X environment (GXE) framework, an interaction between serotonin receptor (5-HTTLPR) gene and drug use would influence suicidal behaviors in BD patients.
|
31707246 |
2020 |
|
Drug usage
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
We hypothesized that, consistent with the gene X environment (GXE) framework, an interaction between serotonin receptor (5-HTTLPR) gene and drug use would influence suicidal behaviors in BD patients.
|
31707246 |
2020 |